01 metabolism 01.01 amino acid metabolism 01.01.01 amino acid biosynthesis 01.01.01.01 assimilation of ammonia, biosynthesis of the glutamate family 01.01.01.03 urea cycle, biosynthesis of polyamines and creatine 01.01.01.05 assimilatory reduction of sulphur and biosynthesis of the serine family 01.01.01.07 biosynthesis of the aspartate family 01.01.01.09 biosynthesis of lysine 01.01.01.09.01 diaminopimelin acid pathway 01.01.01.09.03 aminoadipic acid pathway 01.01.01.11 biosynthesis of the aromatic family 01.01.01.13 biosynthesis of histidine 01.01.01.15 biosynthesis of pyruvate family and D-alanine 01.01.04 regulation of amino acid metabolism 01.01.07 amino acid transport 01.01.10 amino acid degradation (catabolism) 01.01.10.01 degradation of amino acids of the glutamate group 01.01.10.05 degradation of amino acids of the aspartate group 01.01.10.07 degradation of amino acids of the hydroxyaminoacid group 01.01.10.09 degradation of amino acids of the alanine-D-aminoacid group 01.01.99 other amino acid metabolism activities 01.02 nitrogen and sulphur metabolism 01.02.01 nitrogen and sulphur utilization 01.02.04 regulation of nitrogen and sulphur utilization 01.02.07 nitrogen and sulphur transport 01.02.99 other nitrogen and sulphur metabolism activities 01.03 purine, pyrimidine and nucleotide metabolism 01.03.01 purine base and ribonucleotide metabolism 01.03.04 pyrimidine base and ribonucleotide metabolism 01.03.07 deoxyribonucleotide metabolism 01.03.10 metabolism of cyclic and unusual nucleotides 01.03.13 regulation of nucleotide metabolism 01.03.16 polynucleotide degradation 01.03.16.01 RNA degradation 01.03.16.03 DNA degradation 01.03.19 nucleotide transport 01.03.99 other nucleotide metabolism activities 01.04 phosphate metabolism 01.04.01 phosphate utilization 01.04.04 regulation of phosphate utilization 01.04.07 phosphate transport 01.04.99 other phosphate metabolism activities 01.05 C-compound and carbohydrate metabolism 01.05.01 C-compound and carbohydrate utilization 01.05.01.01 C-compound, carbohydrate catabolism 01.05.01.01.01 sugar, glucoside, polyol and carboxylate catabolism 01.05.01.01.03 C-2 compound, organic acid and fatty acid catabolism 01.05.01.01.05 C-1 compound catabolism 01.05.01.01.05.01 serine-isocitrate lyase pathway 01.05.01.01.05.03 ribulose-monophosphate cycle 01.05.01.01.07 aliphatic hydrocarbon catabolism 01.05.01.01.09 aerobic aromate catabolism 01.05.01.01.09.01 aerobic aromate catabolism, ortho-cleavage 01.05.01.01.09.03 aerobic aromate catabolism, meta-cleavage 01.05.01.01.11 anaerobic aromate catabolism 01.05.01.03 C-compound, carbohydrate anabolism 01.05.01.03.01 oligosaccharide / polysaccharide biosynthesis 01.05.01.03.03 aminosaccharide biosynthesis 01.05.01.05 autotrophic CO2 fixation 01.05.01.05.01 Calvin cycle 01.05.01.05.03 reductive TCA cycle 01.05.01.05.05 hydroxypropionate pathway 01.05.01.05.07 acetyl-CoA pathway 01.05.04 regulation of C-compound and carbohydrate utilization 01.05.07 C-compound, carbohydrate transport 01.05.99 other carbohydrate metabolism activities 01.06 lipid, fatty acid and isoprenoid metabolism 01.06.01 lipid, fatty acid and isoprenoid biosynthesis 01.06.01.01 phospholipid biosynthesis 01.06.01.03 glycolipid biosynthesis 01.06.01.05 fatty acid biosynthesis 01.06.01.07 isoprenoid biosynthesis 01.06.01.07.01 hemiterpenes biosynthesis 01.06.01.07.03 monoterpenes biosynthesis 01.06.01.07.05 sesquiterpenes biosynthesis 01.06.01.07.07 diterpenes biosynthesis 01.06.01.07.09 triterpenes biosynthesis 01.06.01.07.11 tetracyclic and pentacyclic triterpenes (steroids and hopanoids) biosynthesis 01.06.01.07.13 tetraterpenes (carotinoids) biosynthesis 01.06.01.07.15 polyterpenes biosynthesis 01.06.04 breakdown of lipids, fatty acids and isoprenoids 01.06.07 lipid, fatty acid and isoprenoid utilization 01.06.10 regulation of lipid, fatty acid and isoprenoid biosynthesis 01.06.13 lipid and fatty acid transport 01.06.16 lipid and fatty acid binding 01.06.99 other lipid, fatty acid and isoprenoid metabolism activities 01.07 metabolism of vitamins, cofactors, and prosthetic groups 01.07.01 biosynthesis of vitamins, cofactors, and prosthetic groups 01.07.04 utilization of vitamins, cofactors, and prosthetic groups 01.07.07 regulation of vitamins, cofactors, and prosthetic groups 01.07.10 transport of vitamins, cofactors, and prosthetic groups 01.07.99 other vitamin, cofactor, and prosthetic group activities 01.20 secondary metabolism 01.20.01 metabolism of primary metabolic sugars derivatives 01.20.01.01 biosynthesis of secondary monosaccharides 01.20.01.03 biosynthesis of sugar carboxylic acids 01.20.01.05 biosynthesis of sugar alcohols 01.20.01.07 biosynthesis of glycosides 01.20.01.09 biosynthesis of aminoglycoside antibiotics 01.20.01.99 other biosynthesis of primary metabolic sugars derivatives 01.20.03 biosynthesis of derivatives of intermediates of glucose degradation 01.20.05 biosynthesis of acetic acid derivatives 01.20.05.01 biosynthesis of acetoacetate, acetone, hydroxybutyric acid 01.20.05.03 biosynthesis of alkanes, alkenes, alkanals, alkanols 01.20.05.05 biosynthesis of fatty acid esters 01.20.05.07 biosynthesis of acetylenes 01.20.05.09 biosynthesis of eicosanoids 01.20.05.11 biosynthesis of polyketides 01.20.05.99 other biosynthesis of acetic acid derivatives 01.20.07 biosynthesis of propionic acid derivatives 01.20.09 biosynthesis of derivatives of intermediates of the TCA and glyoxylate pathway 01.20.13 biosynthesis of derivatives of homoisopentenyl pyrophosphate 01.20.15 biosynthesis of derivatives of dehydroquinic acid, shikimic acid and chorismic acid 01.20.15.01 biosynthesis of naphthoquinone, anthraquinone 01.20.15.03 biosynthesis of ubiquinone 01.20.15.99 other biosynthesis of derivatives of dehydroquinic acid, shikimic acid and chorismic acid 01.20.17 biosynthesis of secondary products derived from primary amino acids 01.20.17.01 biosynthesis of nonprotein amino acids 01.20.17.03 biosynthesis of amines 01.20.17.05 biosynthesis of cyanogenic glycosides 01.20.17.07 biosynthesis of glycosinolates and derivatives 01.20.17.09 biosynthesis of alkaloids 01.20.19 biosynthesis of secondary products derived from glycine, L-serine and L-alanine 01.20.19.01 biosynthesis of porphyrins 01.20.19.03 biosynthesis of tetrapyrrols 01.20.19.05 biosynthesis of cobalamins 01.20.19.99 other biosynthesis of secondary products derived from glycine, L-serine and L-alanine 01.20.21 biosynthesis of sulphuric acid and L-cysteine derivatives 01.20.23 biosynthesis of L-methionine derived secondary products 01.20.25 biosynthesis of secondary products originating from L-valin, L-leucine and L-isoleucine 01.20.27 biosynthesis of secondary products built from L-aspartic acid and L-threonine 01.20.29 biosynthesis of secondary products derived from L-glutamic acid, L-proline and L-ornithine 01.20.31 biosynthesis of secondary products derived from L-lysine, L-arginine and L-histidine 01.20.33 biosynthesis of secondary products built from L-tryptophan 01.20.35 biosynthesis of secondary products derived from L-phenylalanine and L-tyrosine (phenylpropanoids) 01.20.35.01 biosynthesis of melanins 01.20.35.03 biosynthesis of lignins 01.20.35.05 biosynthesis of stilbenes, flavonoids 01.20.35.07 biosynthesis of coumarins 01.20.35.09 biosynthesis of cinnamic acids 01.20.35.99 other biosynthesis of phenylpropanoids 01.20.37 biosynthesis of peptide derived compounds 01.20.37.01 biosynthesis of thioredoxin, glutaredoxin, glutathion 01.20.37.03 biosynthesis of peptide antibiotics 01.20.37.05 biosynthesis of beta-lactams 01.20.37.99 other biosynthesis of peptide derived compounds 01.20.99 other secondary metabolism activities 02 energy 02.01 glycolysis and gluconeogenesis 02.01.01 glycolysis methylglyoxal bypass 02.05 Entner-Doudoroff pathway 02.07 pentose-phosphate pathway 02.07.01 pentose-phosphate pathway oxidative branch 02.07.03 pentose-phosphate pathway non oxidative branch 02.09 anaplerotic reactions 02.10 tricarboxylic acid pathway 02.11 electron transport and membrane-associated energy conservation 02.11.01 electron transport proteins 02.11.03 ATP synthesis proteins 02.11.05 accessory proteins of electron transport and membrane-associated energy conversation 02.11.99 other electron transport and membrane-associated energy conservation proteins 02.13 respiration 02.13.01 anaerobic respiration 02.13.03 aerobic respiration 02.16 fermentation 02.16.01 alcohol fermentation, pyruvate dehydrogenase bypass 02.16.01.01 bacterial type ethanol fermentation 02.16.01.99 other ethanol fermentation 02.16.03 lactate fermentation 02.16.03.01 homofermentative pathway 02.16.03.03 heterofermentative pathway and fermentation of other saccharides 02.16.03.05 bifidium pathway 02.16.03.07 malo-lactate fermentation 02.16.05 butyrate and butanol-acetone fermentation 02.16.07 ethanol-acetate fermentation 02.16.09 mixed acid and butanediol fermentation 02.16.11 propionate fermentation, methylcitrate cycle 02.16.11.01 acrylate pathway 02.16.11.03 succinate-propionate pathway 02.16.13 acetate fermentation 02.16.15 methane fermentation 02.16.17 fermentation of nitrogenous compounds 02.16.17.01 single amino acid fermentations 02.16.17.03 stickland reactions 02.16.17.05 fermentation of heterocyclic compounds 02.16.99 other fermentation proteins 02.17 chemolithotrophie (sulfide, nitrogenous compounds) 02.19 metabolism of energy reserves (glycogen, trehalose) 02.22 glyoxylate cycle 02.25 oxidation of fatty acids 02.30 photosynthesis 02.30.01 electron transport proteins of photosynthesis 02.30.03 accessory proteins of photosynthetic electron transport 02.99 other energy generation activities 03 cell growth, cell division and DNA synthesis 03.01 cell growth 03.04 budding, cell polarity and filament formation 03.07 pheromone response, mating-type determination, sex-specific proteins 03.10 sporulation and germination 03.13 meiosis 03.16 DNA synthesis and replication 03.19 recombination and DNA repair 03.22 cell cycle control and mitosis 03.22.01 cell cycle check point proteins 03.25 cytokinesis 03.26 growth regulators 03.99 other cell growth, cell division and DNA synthesis activities 04 transcription 04.01 rRNA transcription 04.01.01 rRNA synthesis 04.01.04 rRNA processing 04.01.99 other rRNA-transcription activities 04.03 tRNA transcription 04.03.01 tRNA synthesis 04.03.03 tRNA processing 04.03.06 tRNA modification 04.03.99 other tRNA-transcription activities 04.05 mRNA transcription 04.05.01 mRNA synthesis 04.05.01.01 general transcription activities 04.05.01.04 transcriptional control 04.05.01.07 chromatin modification 04.05.03 mRNA processing (splicing) 04.05.05 mRNA processing (5'-, 3'-end processing, mRNA degradation) 04.05.99 other mRNA-transcription activities 04.07 RNA transport 04.99 other transcription activities 05 protein synthesis 05.01 ribosomal proteins 05.04 translation (initiation, elongation and termination) 05.07 translational control 05.10 tRNA-synthetases 05.99 other protein synthesis activities 06 protein destination 06.01 protein folding and stabilization 06.04 protein targeting, sorting and translocation 06.07 protein modification (glycosylation, acylation, myristylation, palmitylation and farnesylation) 06.10 assembly of protein complexes 06.13 proteolysis 06.13.01 cytoplasmic degradation 06.13.04 lysosomal and vacuolar degradation 06.13.07 mitochondrial degradation 06.20 storage proteins 06.99 other protein-destination activities 07 transport facilitation 07.01 ion channels 07.04 ion transporters 07.04.01 metal ion transporters (Cu, Fe, etc) 07.04.04 other cation transporters (Na, K, Ca, NH4, etc) 07.04.07 anion transporters (Cl, SO4, PO4, etc) 07.07 sugar, carbohydrate and metabolite transporters 07.07.01 phosphotransferase systems 07.10 amino acid transporters 07.11 peptide transporters 07.13 lipid transporters 07.16 purine and pyrimidine transporters 07.19 allantoin and allantoate transporters 07.22 transport ATPases 07.25 ABC transporters 07.28 drug transporters 07.30 protein secretion systems 07.30.03 type I protein secretion system 07.30.05 type II protein secretion system 07.30.07 type III protein secretion system 07.30.09 type IV protein secretion system 07.30.11 other protein secretion systems 07.99 other transport facilitators 08 intracellular transport 08.01 nuclear transport 08.02 chloroplast transport 08.04 mitochondrial transport 08.07 vesicular transport (Golgi network, etc) 08.10 peroxisomal transport 08.13 vacuolar transport 08.16 extracellular transport (secretion) 08.19 cellular import 08.22 cytoskeleton-dependent transport 08.99 other intracellular-transport activities 09 cellular biogenesis (proteins are not localized to the corresponding organelle) 09.01 biogenesis of cell wall (cell envelope) 09.02 biogenesis of plasma membrane 09.03 biogenesis of cytoplasm 09.04 biogenesis of cytoskeleton 09.07 biogenesis of endoplasmic reticulum 09.08 biogenesis of Golgi 09.09 biogenesis of intracellular transport vesicles 09.10 nuclear biogenesis 09.13 biogenesis of chromosome structure 09.16 mitochondrial biogenesis 09.19 peroxisomal biogenesis 09.22 endosomal biogenesis 09.25 vacuolar and lysosomal biogenesis 09.26 chloroplast biogenesis 09.27 biogenesis of outer membrane 09.28 biogenesis of periplasmic space 09.29 biogenesis of inner membrane 09.30 biogenesis of flagellae 09.33 biogenesis of pili 09.99 other cellular biogenesis activities 10 cellular communication/signal transduction 10.00 intercellular communication 10.00.01 pheromones 10.00.03 hormones 10.00.05 cytokines 10.01 intracellular communication 10.01.01 unspecific signal transduction 10.01.01.01 signal transduction, receptor proteins 10.01.01.03 signal transduction, second messenger formation and breakdown 10.01.01.05 signal transduction, mediator proteins 10.01.01.07 signal transduction, G-proteins 10.01.01.09 signal transduction, regulation of G-protein activity 10.01.01.11 signal transduction, key kinases 10.01.01.13 signal transduction, key phosphatases 10.01.01.15 two-component signal transduction 10.01.01.99 other unspecified signal transduction activities 10.01.05 morphogenesis 10.01.05.01 morphogenesis, receptor proteins 10.01.05.03 morphogenesis, second messenger formation and breakdown 10.01.05.07 morphogenesis, G-proteins 10.01.05.09 morphogenesis, regulation of G-protein activity 10.01.05.11 morphogenesis, key kinases 10.01.05.13 morphogenesis, key phosphatases 10.01.05.99 other morphogenetic activities 10.01.10 osmosensing 10.01.10.01 osmosensing, receptor proteins 10.01.10.05 osmosensing, mediator proteins 10.01.10.11 osmosensing, key kinases 10.01.10.13 osmosensing, key phosphatases 10.01.10.99 other osmosensing activities 10.01.15 nutritional response pathway 10.01.15.01 nutritional response pathway, receptor proteins 10.01.15.03 nutritional response pathway, second messenger formation and breakdown 10.01.15.05 nutritional response pathway, mediator proteins 10.01.15.07 nutritional response pathway, G-proteins 10.01.15.09 nutritional response pathway, regulation of G-protein activity 10.01.15.11 nutritional response pathway, key kinases 10.01.15.13 nutritional response pathway, key phosphatases 10.01.15.99 other nutritional reponse activities 10.01.20 pheromone response generation 10.01.20.01 pheromone response generation, receptor proteins 10.01.20.07 pheromone response generation, G-proteins 10.01.20.09 pheromone response generation, regulation of G-protein activity 10.01.20.11 pheromone response generation, key kinases 10.01.20.13 pheromone response generation, key phosphatases 10.01.20.99 other pheromone response activities 10.01.99 other signal-transduction activities 11 cell rescue, defense, cell death and ageing 11.01 stress response 11.04 DNA repair (direct repair, base excision repair and nucleotide excision repair) 11.05 disease, virulence and defense 11.05.01 resistance proteins 11.05.03 defense related proteins 11.05.05 virulence, disease factors 11.05.05.01 toxins 11.05.05.03 bacteriocins 11.05.05.05 invasins 11.05.05.07 adhesins 11.05.05.09 capsule 11.05.05.11 DNA restriction and modification 11.05.05.13 major antigenic determinants 11.05.05.99 other virulence, disease factors 11.05.99 other disease and defense related proteins 11.07 detoxification 11.07.01 detoxification involving cytochrome p450 11.07.02 defence against oxidative stress 11.07.03 detoxification by modification 11.07.05 detoxification by export 11.07.99 other detoxification 11.10 cell death 11.11 ageing 11.13 degradation of exogenous polynucleotides 11.15 degradation of exogenous proteins 11.17 degradation of exogenous polysaccharides 11.19 degradation of exogenous ester compounds 11.99 lignin degradation 13 ionic homeostasis 13.01 homeostasis of metal ions 13.04 homeostasis of other ions 30 cellular organization (proteins are localized to the corresponding organelle) 30.01 organization of cell wall 30.02 organization of plasma membrane 30.03 organization of cytoplasm 30.04 organization of cytoskeleton 30.05 organization of centrosome 30.07 organization of endoplasmic reticulum 30.08 organization of Golgi 30.09 organization of intracellular transport vesicles 30.10 nuclear organization 30.13 organization of chromosome structure 30.16 mitochondrial organization 30.19 peroxisomal organization 30.22 endosomal organization 30.25 vacuolar and lysosomal organization 30.26 chloroplast organization 30.27 outer membrane organization 30.28 periplasmic space organization 30.29 inner membrane organization 30.30 flagellar organization 30.33 pilus organization 30.90 extracellular/secretion proteins 30.99 other cellular organization 35 motility 35.01 chemotaxis 35.02 phototaxis 50 development 50.01 differentiation of prokaryotes 50.02 development of eukaryotes 50.02.01 fungal development 50.02.02 development of plants 50.02.03 development of mammals 90 transposon, insertion sequence and plasmid proteins 90.01 LTR retroelements 90.02 non-LTR retroelements 90.99 other transposons and plasmid proteins 96 ribosomal RNA 97 cloning vector or bacterial contaminant 98 plant host gene 99 unclassified protein